methylphenidate will decrease the level or effect of benazepril by pharmacodynamic antagonism. Use Caution/Monitor. Methylphenidate is contraindicated during treatment with an MAOI and also within a minimum of 14 days following discontinuation of an MAOI. Monitor Closely (1)methylphenidate will decrease the level or effect of clevidipine by pharmacodynamic antagonism. yohimbe, methylphenidate. Monitor Closely (1)methylphenidate will decrease the level or effect of amlodipine by pharmacodynamic antagonism. thiothixene increases toxicity of methylphenidate by pharmacodynamic antagonism. methylphenidate will decrease the level or effect of phentolamine by pharmacodynamic antagonism. methylphenidate will decrease the level or effect of clevidipine by pharmacodynamic antagonism. Use Caution/Monitor. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. ethanol increases levels of methylphenidate by enhancing GI absorption. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided. Applies only to oral form of both agents. CNS stimulant should be discontinued at least 48 hours before myelography, should not be used for the control of nausea or vomiting during or after myelography, and should not be resumed for at least 24 hours postprocedure. Increased pH may enhance the release of the drug from delayed release formulations. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. Additive pressor effect. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. only. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. Mechanism: unknown. Methylphenidate may diminish antihypertensive effects. Use Caution/Monitor. Use Caution/Monitor. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Methylphenidate may diminish antihypertensive effects. Additive vasospasm; risk of hypertension. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Use Caution/Monitor. Mechanism: unknown. Monitor Closely (1)methamphetamine increases effects of methylphenidate by pharmacodynamic synergism. dihydroergotamine intranasal, methylphenidate. methylphenidate increases toxicity of trazodone by Other (see comment). Contraindicated. Use Caution/Monitor. Contraindicated. Contraindicated (1)tranylcypromine increases effects of methylphenidate by pharmacodynamic synergism. Monitor for increased serum concentrations/toxicity of phenytoin if methylphenidate is initiated/dose increased, or decreased concentrations/effects if methylphenidate is discontinued/dose decreased. Serious - Use Alternative (1)ether increases toxicity of methylphenidate by Mechanism: unknown. Serious - Use Alternative (1)methoxyflurane increases toxicity of methylphenidate by Mechanism: unknown. To view formulary information first create a list of plans. This drug is available at the lowest co-pay. lurasidone, methylphenidate. Methylphenidate is contraindicated during treatment with an MAOI and also within a minimum of 14 days following discontinuation of an MAOI. Table 3. Applies only to oral form of both agents. Methylphenidate is contraindicated during treatment with an MAOI and also within a minimum of 14 days following discontinuation of an MAOI. loxapine inhaled increases toxicity of methylphenidate by pharmacodynamic antagonism. Monitor Closely (1)dextroamphetamine increases effects of methylphenidate by pharmacodynamic synergism. Use Caution/Monitor. Mechanism: pharmacodynamic synergism. Coadministration of drugs that affect the serotonergic neurotransmitter system may result in serotonin syndrome. only. Attention deficit hyperactivity disorder ( ADHD) medications are usually stimulants. Sympathomimetics can antagonize the activity of some antihypertensive agents. Use Caution/Monitor. Monitor Closely (1)iloperidone increases toxicity of methylphenidate by pharmacodynamic antagonism. Monitor Closely (1)methylphenidate will decrease the level or effect of isradipine by pharmacodynamic antagonism. Interaction more likely in certain predisposed pts. Monitor BP. Applies only to oral form of both agents. 10 mg, 15 mg, 20 mg, 30 mg, 40 mg, 50 mg, 60 mg. lisdexamfetamine increases effects of methylphenidate by pharmacodynamic synergism. Other (see comment). Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Avoid or Use Alternate Drug. methylphenidate will decrease the level or effect of propranolol by pharmacodynamic antagonism. Your list will be saved and can be edited at any time. Use Caution/Monitor. Avoid or Use Alternate Drug. Use Caution/Monitor. Capsule may be opened and contents swallowed completely with applesauce. This means that you only need to take. Mechanism: unknown. Contraindicated. Monitor Closely (1)methylphenidate will decrease the level or effect of phentolamine by pharmacodynamic antagonism. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. Interaction more likely in certain predisposed pts. Serious - Use Alternative (1)methylergonovine, methylphenidate. Applies only to oral form of both agents. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. Methylphenidate may diminish antihypertensive effects. Most Use Caution/Monitor. Methylphenidate may diminish antihypertensive effects. Modify Therapy/Monitor Closely. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Methylphenidate may diminish antihypertensive effects. Monitor Closely (1)methylphenidate will decrease the level or effect of nifedipine by pharmacodynamic antagonism. Interaction specifically associated with Ritalin LA. Interaction more likely in certain predisposed pts. calcium carbonate decreases effects of methylphenidate by enhancing GI absorption. Monitor BP. Use Caution/Monitor. Use Caution/Monitor. promethazine, methylphenidate. Contraindicated. Risk of acute hypertensive episode. Methylphenidate may diminish antihypertensive effects. aluminum hydroxide decreases effects of methylphenidate by enhancing GI absorption. Monitor Closely (1)methylphenidate will increase the level or effect of atomoxetine by pharmacodynamic synergism. Contraindicated (1)phenelzine increases effects of methylphenidate by pharmacodynamic synergism. Methylphenidate is contraindicated during treatment with an MAOI and also within a minimum of 14 days following discontinuation of an MAOI. Use Caution/Monitor. imipramine, methylphenidate. Monitor BP. Applies only to oral form of both agents. Risk of acute hypertensive episode. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. The above information is provided for general Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Modify Therapy/Monitor Closely. Monitor BP. Interaction more likely in certain predisposed pts. Monitor BP. Contraindicated. Contraindicated. methylphenidate will decrease the level or effect of isradipine by pharmacodynamic antagonism. esomeprazole decreases effects of methylphenidate by enhancing GI absorption. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Applies to long-acting formulation of methylphenidate where coadministration with alcohol may result in more rapid release. Methylphenidate is contraindicated during treatment with an MAOI and also within a minimum of 14 days following discontinuation of an MAOI. Other (see comment). Monitor Closely (1)fenfluramine and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Mechanism: pharmacodynamic antagonism. Serious - Use Alternative (1)ergotamine, methylphenidate. Dosing recommendations are based on current dose regimen and clinical judgment. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided. Avoid or Use Alternate Drug. Applies only to oral form of both agents. This drug is available at a middle level co-pay. Use Caution/Monitor. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided. Use Caution/Monitor. Use Caution/Monitor. Conversion dosage should not exceed 72 mg daily. Monitor BP. Use Caution/Monitor. Contraindicated. Other (see comment). caffeine increases effects of methylphenidate by pharmacodynamic synergism. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Methylphenidate is contraindicated during treatment with an MAOI and also within a minimum of 14 days following discontinuation of an MAOI. methylphenidate will increase the level or effect of phenobarbital by unknown mechanism. Concerta is a long-acting drug: It increases dopamine steadily. Methylphenidate may diminish antihypertensive effects. Modify Therapy/Monitor Closely. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided. Risk of acute hypertensive episode. Use Caution/Monitor. Methylphenidate may diminish antihypertensive effects. Use Caution/Monitor. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided. Monitor BP. methylphenidate will decrease the level or effect of telmisartan by pharmacodynamic antagonism. Use Caution/Monitor. Discontinue interfering drugs for at least 5 half-lives before administration of either the dosimetry or an iobenguane dose. Use Caution/Monitor. Use Caution/Monitor. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Monitor BP. Use Caution/Monitor. methylphenidate will decrease the level or effect of sotalol by pharmacodynamic antagonism. Use Caution/Monitor. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. Serious - Use Alternative (1)sevoflurane increases toxicity of methylphenidate by Mechanism: unknown. methylphenidate will decrease the level or effect of nicardipine by pharmacodynamic antagonism. methylphenidate increases effects of warfarin by unspecified interaction mechanism. Use Caution/Monitor. Monitor Closely (1)pimozide increases toxicity of methylphenidate by pharmacodynamic antagonism. Use Caution/Monitor. Monitor Closely (1)quetiapine increases toxicity of methylphenidate by pharmacodynamic antagonism. Use Caution/Monitor. Monitor Closely (2)perphenazine, methylphenidate. Long-acting Stimulant Conversion Guide Prescribers, at times, may need to switch patients from one stimulant to another due to various reasons including patient . Either increases toxicity of the other by sympathetic (adrenergic) effects, including increased blood pressure and heart rate. phentermine increases effects of methylphenidate by pharmacodynamic synergism. Either increases effects of the other by pharmacodynamic synergism. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. Other (see comment). Monitor Closely (1)bromocriptine, methylphenidate. Monitor Closely (1)isoproterenol and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Risk of acute hypertensive episode. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Use Caution/Monitor. Methylphenidate may diminish antihypertensive effects. isoproterenol and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)dobutamine and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. serdexmethylphenidate/dexmethylphenidate and methylphenidate both decrease sedation. methylphenidate decreases effects of iopamidol by unspecified interaction mechanism. Mechanism: pharmacodynamic antagonism. Applies to long-acting formulation of methylphenidate where coadministration with alcohol may result in more rapid release. Please confirm that you would like to log out of Medscape. only. Modify Therapy/Monitor Closely. Avoid or Use Alternate Drug. Use Caution/Monitor. Monitor BP. Use Caution/Monitor. Risk of acute hypertensive episode. If concomitant use is warranted, carefully observe the patient, particularly during treatment initiation and dose adjustment. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Monitor Closely (1)methylphenidate will decrease the level or effect of terazosin by pharmacodynamic antagonism. Use Caution/Monitor. commonly, these are generic drugs. Avoid or Use Alternate Drug. methylphenidate will decrease the level or effect of nimodipine by pharmacodynamic antagonism. Use Caution/Monitor. Methylphenidate may diminish antihypertensive effects. Use Caution/Monitor. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. Use Caution/Monitor. restrictions. Use Caution/Monitor. Risk of acute hypertensive episode. Use Caution/Monitor. Monitor Closely (1)loxapine increases toxicity of methylphenidate by pharmacodynamic antagonism. Contraindicated (1)isocarboxazid increases effects of methylphenidate by pharmacodynamic synergism. Use Caution/Monitor. Methylphenidate may diminish antihypertensive effects. Monitor BP. methamphetamine increases effects of methylphenidate by pharmacodynamic synergism. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Monitor BP. Use Caution/Monitor. Modify Therapy/Monitor Closely. haloperidol increases toxicity of methylphenidate by pharmacodynamic antagonism. Monitor Closely (1)formoterol and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Monitor Closely (1)hydrocodone, methylphenidate. methylphenidate will decrease the level or effect of enalapril by pharmacodynamic antagonism. Use Caution/Monitor. Use Caution/Monitor. rotigotine, methylphenidate. informational and educational purposes only. Monitor for increased serum concentrations/toxicity of phenytoin if methylphenidate is initiated/dose increased, or decreased concentrations/effects if methylphenidate is discontinued/dose decreased. The recommended dose of CONCERTA for patients who are currently taking methylphenidate twice daily or three times daily at doses of 10 to 60 mg/day is provided in Table 2. Monitor Closely (1)calcium carbonate decreases effects of methylphenidate by enhancing GI absorption. Safinamide. trifluoperazine, methylphenidate. Use Caution/Monitor. Use Caution/Monitor. Other (see comment). Coadministration of drugs that affect the serotonergic neurotransmitter system may result in serotonin syndrome. Desflurane. Either increases effects of the other by serotonin levels. isoflurane increases toxicity of methylphenidate by Mechanism: unknown. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. methyldopa increases effects of methylphenidate by unknown mechanism. Other (see comment). Risk of acute hypertensive episode. Interaction more likely in certain predisposed pts. Use Caution/Monitor. Monitor Closely (1)desipramine, methylphenidate. Methylphenidate may diminish antihypertensive effects. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)imipramine, methylphenidate. Modify Therapy/Monitor Closely. Either increases effects of the other by pharmacodynamic synergism. Potential for additive CNS stimulation. Monitor BP. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided. Avoid or Use Alternate Drug. Methylphenidate is contraindicated during treatment with an MAOI and also within a minimum of 14 days following discontinuation of an MAOI. Applies only to oral form of both agents. methylphenidate will decrease the level or effect of perindopril by pharmacodynamic antagonism. Risk of acute hypertensive episode. Check specific recommendations for drugs that exhibit pH-dependent solubility that may affect their systemic exposure and efficacy. Methylphenidate may diminish antihypertensive effects. Monitor Closely (1)methylphenidate will increase the level or effect of phenobarbital by unknown mechanism. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Other (see comment). Modify Therapy/Monitor Closely. Mechanism: unknown. . Methylphenidate may diminish antihypertensive effects. Risk of acute hypertensive episode. Either increases effects of the other by serotonin levels. Applies only to oral form of both agents. Monitor for hypertension with concomitant use. Monitor Closely (1)trimipramine, methylphenidate. Use Caution/Monitor. Modify Therapy/Monitor Closely. Other (see comment). Monitor BP. lofepramine, methylphenidate. Modify Therapy/Monitor Closely. Use Caution/Monitor. Monitor BP. cariprazine increases toxicity of methylphenidate by pharmacodynamic antagonism. Applies only to oral form of both agents. Use Caution/Monitor. Most Monitor Closely (1)green tea, methylphenidate. Avoid or Use Alternate Drug. methylphenidate will decrease the level or effect of prazosin by pharmacodynamic antagonism. Use Caution/Monitor. esketamine intranasal, methylphenidate. Monitor BP. Use Caution/Monitor. 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Calcium carbonate decreases effects of the antacid and the methylphenidate extended-release capsules may be.! Warfarin by unspecified interaction Mechanism Closely monitor for signs of altered clinical response to either methylphenidate an! Than other phenothiazines of clevidipine by pharmacodynamic synergism pharmacodynamic antagonism esomeprazole decreases effects of the other by other ( comment.
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